Transcription and epigenetics
نویسندگان
چکیده
منابع مشابه
Introduction to theme "Chromatin, epigenetics, and transcription".
Transcriptional regulation in eukaryotes depends on a complex network of interactions between RNA polymerases and a host of transcription factors and coregulators that control their activity during transcription initiation and elongation. Among these are an enormous variety of enzymes and proteins that modulate chromatin structure via changes in DNA methylation, histone modifications, and nucle...
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The concept of ‘epigenetics’ is comparatively newer and less known section in ‘biomolecular science. However, this has gained immense interest among modern molecular biologists. This is a field of study, which deals with the changes of genetic expression affecting the cellular phenotypes caused by the modifications of DNA materials other than change of nucleotide sequence. Literally, ‘Epigeneti...
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Myogenic regulatory factor (MRF) genes, MYOD1, MYOG, MYF6 and MYF5, are critical for the skeletal muscle lineage. Here, we used various epigenome profiles from human myoblasts (Mb), myotubes (Mt), muscle and diverse non-muscle samples to elucidate the involvement of multigene neighborhoods in the regulation of MRF genes. We found more far-distal enhancer chromatin associated with MRF genes in M...
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ژورنال
عنوان ژورنال: Nature
سال: 2013
ISSN: 0028-0836,1476-4687
DOI: 10.1038/502461a